Napredni reagenti za (asimetrično) nukleofilno fluoriranje|
Oznaka in naziv projekta
N1-0185 Napredni reagenti za (asimetrično) nukleofilno fluoriranje
N1-0185 Advanced reagents for (asymmetric) nucleophilic fluorination
Logotipi ARRS in drugih sofinancerjev
Projektna skupina
Vodja projekta: doc. dr. Gašper Tavčar
dr. Melita Tramšek
Sodelujoče raziskovalne organizacije: Povezava na SICRIS
Sestava projektne skupine: Povezava na SICRIS
Vsebinski opis projekta
Although the proposed research represents homogeneous subject, devoted to the development of novel nucleophilic fluorination reagents and their application to selected classes of substrates, it can be divided into individual WP’s, connected closely together. Thus, WP1 will concentrate on the synthesis of sterically hindered imidazolium salts and imidazoles, either fluorinated on C2 of the heterocyclic ring or having fluoride or polyhydrogenpolyfluoride anion; WP2 will synthesize various variants of fluorinated pentacoordinated silicon species with the emphasis on alkyldiaryldifluorosilicates and various cations included imidazolium salts developed in WP1; WP3 devoted to the synthesis of asymmetric variants of reagents synthesized in WP1 and WP2 with the emphasis on the develoment of new chiral group, [2.2]paracyclophan-4-yl modified with alkyl substituents in position 5; WP4, where reagents prepared in WP’s 1-3 will be tested both on model compounds and pharmaceutically interesting substances; and, finally, WP5, which will be devoted to environmental aspects of the project including recycle of the spent reagents or their potential applications in catalytic amounts in connection with cheap fluorinating reagents. The details of individual WP’s are given below.
Osnovni podatki sofinanciranja so dostopni na spletni strani SICRIS.
Faze projekta in opis njihove realizacije (ang)
WP1 Development of imidazolium based nucleophilic fluorinating reagents
WP2 Development of hypervalent silicon based nucleophilic fluorinating reagents
WP3 Development of chiral nucleophilic fluorinating reagents
WP4 Reactivity of prepared nucleophilic fluorinating reagents in organic chemistry
WP5 Evaluation of economic and environmental potential of new reagents for use on industrially relevant systems
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