K3-en / Iskra

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Prof. Dr. JERNEJ ISKRA, senior research associate ( Slovensko )

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Address:

Department of Physical and Organic Chemistry
Jožef Stefan Institute
Jamova 39, 1000 Ljubljana, Slovenia

Phone:

+386 1 4773 631

FAX:

+386 1 4773 822

E-mail:

jernej.iskra at ijs.si

Scientific Interest:

Halogenation and oxidation reactions with the emphasis on "green" chemistry and bioactive cyclic peroxides

Researcher ID

A-1777-2008

ORCID

0000-0001-6340-3577


Education

  • B. Sc. in chemistry, 1993 - University of Ljubljana, Slovenia

  • Ph. D. in chemistry, 1998 - University of Ljubljana

Scientific and professional carrier

  • 2016-: Associate Professor, Faculty of Chemistry and Chemical Technology, University of Ljubljana

  • 2016-: Associate Professor, Faculty of Chemistry and Chemical Technology, University of Maribor

  • 2015-: Associate Professor, Jožef Stefan International Postgraduate School

  • 2009–: Senior Research Associate, Jožef Stefan Institute

Positions

  • 1999–: Jožef Stefan Institute (Senior Research Associate).

  • 2016-: Faculty of Chemistry and Chemical Technology, University of Ljubljana(Professor)

  • 2014-: Startup company - RGA, Research Genetics and Agrochemistry, Ltd. (Founder, COE) (spin-out company of Jožef Stefan Institute.

  • 2011–2016: Faculty of Chemistry and Chemical Technology, University of Maribor (professor, part time)

  • 2010–2014: Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins (Senior Research Associate, part time).

Fellowships and awards

  • 2015: Start:up Slovenija 2015 (semifinal, 3. place, RGA: »De novo« Wheat or how to fix degeneration of species, Primož Titan, Jernej Iskra)

  • 2014: Excellence in Science 2013 – chemistry, Slovenian Research Agency (Iodine(I) reagents in hydrochloric acid-catalyzed oxidative iodination of aromatic compounds by hydrogen peroxide and iodine)

  • 2014: Silver award for innovation of Chamber of Commerce and Industry of Dolenjska and Bela krajina - Innventive procedure for production of bioactive compound and its incorporation into pharmaceutical products for treatment of infections on animals (joint project with Krka d.d.)

  • 2013: Innovation with best commercial potential from public research organizations (Day of innovation, Chamber of Commerce and Industry of the Republic of Slovenia) - Corrosion protection with hybrid sol-gel coating (first place, innovation of the Department K-3)

  • 2012: Rector's award for best innovation of University of Ljubljana - Hybrid sol-gel coatings for protection against corrosion of aluminium and its alloys(third place, innovation of the Department K-3)

  • 2010: Rector's award for best innovation of University of Ljubljana - Use of chemical hybridization of exploitation of heterosis in common wheat (Triticum aestivum L.) (finalist, joint project with Semenarna d.d.)

  • 2008: Silver award for innovation of Chamber of Commerce and Industry of Dolenjska and Bela krajina - Procedure for preparation of 2-sulfynil-1H-benzimidazoles (joint project with Krko d.d.)

  • 2000-2002: Marie Curie Individual Fellowship, BioCIS, University Paris XI, 2000-2002 (Jean-Pierre Bégué and Danièle Bonnet-Delpon)

Current research interests:

K3/slikajernej

Green chemistry :

new methods and reaction systems for improvement of environmental parameters of chemical reactions (alternative media, recyclable reagents, solid-supported reagents, bimimetic conditions, catalytic conditions).

Oxidative halogenation :

research and development of new methods and reagents for halogenation and oxidation of organic compounds with air or hydrogen peroxide.

Bioactive organic peroxides :

new methods of peroxidation of carbonyl compounds as an entry for synthesis of bioactive organic peroxides (i.e. antimalarial tetraoxanes, antitubercular…).

Fluorinated alcohols :

Fluorinated alcohols as template catalysis for enhancement of reactivity in catalyzed and non-catalyzed oxidation processes (aerobic oxidation, peroxidation, halogenation, nitration…).

Personal bibliograhy

  • Personal bibliography can be obtained from Cobiss.si; click here and wait a bit.

Selected publications

  1. Š. Možina, S. Stavber, J. Iskra, "Dual Catalysis for aerobic oxidation of benzyl alcohols - nitric acid and fluorinated alcohol",
    Eur. J. Org. Chem, 2016, DOI: 10.1002/ejoc.201601339.

  2. K. Starkl Renar, I. Križaj, J. Iskra, "Understanding malarial toxins",
    Toxicon, 2016, 119, 319-329.

  3. K. Starkl Renar, S. Pečar, J. Iskra, "Activation of aqueous hydrogen peroxide for non-catalyzed dihydroperoxidation of ketones by azeotropic removal of water",
    Org. Biomol. Chem., 2015, 13, 9369–9372.

  4. L. Bedrač, J. Iskra, "Iodine(I) reagents in hydrochloric acid-catalyzed oxidative iodination of aromatic compounds by hydrogen peroxide and iodine",
    Adv. Synth. Catal., 2013, 355, 1243-1248.

  5. J. Iskra, ed., "Halogenated heterocycles: synthesis, application and environment, (Topics in heterocyclic chemistry, 27)", Heidelberg, Springer, 2012.

  6. Podgoršek, M. Zupan, J. Iskra, "Oxidative Halogenation with “Green” Oxidants: Oxygen and Hydrogen Peroxide",
    Angewandte Chemie, 2009, 48, 8424-8450.

  7. A. Podgoršek, M. Eissen, J. Fleckenstein, S. Stavber, M. Zupan, J. Iskra, "Selective aerobic oxidative dibromination of alkenes with aqueous HBr and sodium nitrite as a catalyst",
    Green Chemistry, 2009, 11, '120-126.

  8. A. Podgoršek, S. Stavber, M. Zupan, J. Iskra, A. A. H. Padua, M. Costa Gomes, "Solvation of halogens in fluorous phases, Experimental and simulation data for F2, Cl2 and Br2 in several fluorinated liquids",
    Journal of Physical Chemistry B, 2008, 112, 6653-6664.

  9. G. Stavber, J. Iskra, M. Zupan, S. Stavber, "Aerobic oxidative iodination of organic compounds with iodide catalyzed by sodium nitrite"
    Advanced Synthesis & Catalysis, 2008, 350, 2921-2929.

  10. A. Podgoršek, S. Stavber, M. Zupan, J. Iskra, "Bromination of Ketones with H2O2-HBr “On Water",
    Green Chemistry, 2007, 9, 1212-1218

  11. K. Žmitek, M. Zupan, S. Stavber, J. Iskra, "The Effect of Iodine on the Peroxidation of Carbonyl Compounds",
    Journal of Organic Chemistry, 2007, 72, 6534-6540

  12. K. Žmitek, S. Stavber, M. Zupan, D. Bonnet-Delpon, S. Charneau, P. Grellier, J. Iskra, "Synthesis and Antimalarial Activities of Novel 3,3,6,6-Tetraalkyl-1,2,4,5-Tetraoxanes",
    Bioorganic Medicinal Chemistry, 2006, 14, 7790-7795

  13. J. Iskra, S. Stavber, M. Zupan, "Nonmetal-Catalyzed Iodination of Arenes with Iodide and Hydrogen Peroxide",
    Synthesis, 2004, 1868-1873

  14. J. Iskra, S. Stavber, M. Zupan, "Use of a Fluorous Bridge for Diffusion Controlled Uptake of Molecular Chlorine in Chlorine Addition to Alkenes",
    Chemical Communications, 2003, 2496-2497

  15. M. Zupan, J. Iskra, S. Stavber, "Regioselective Conversions of 1-Phenyl-substituted Acetylenes to (alfa),(alfa)-Difluoro Ketones with F-TEDA-BF4",
    Journal of Organic Chemistry, 1995, 60, 259-260

Patents

  1. J. Iskra, S. Stavber, B. Kotar Jordan, M. Ruzic, J. Smodis, R. Zupet, "PROCESS FOR PREPARING 2-SULFINYL-1H-BENZIMIDAZOLES",
    EA018796 (B1), 2013-10-30, KRKA TOVARNA ZDRAVIL, d. d., NOVO MESTO.

  2. R. Zupet, A. Pečavar, J. Iskra, M. Ružič, I. Kolenc, "A process for a preparation of marbofloxacin and intermediate thereof",
    EA021239 (B1), 2015-05-29, KRKA TOVARNA ZDRAVIL, d. d., NOVO MESTO.
    .